Works flawlessly in DOSBox 0.73 and 0.74. The only problem is that when selecting Sound Blaster 16 manually in the sound setup (which is the default sound card that DOSBox emulates), you'll only get 8-bit mono audio. To get 16-bit stereo sound, edit HMISET.CFG and change "DeviceDMA = 1" to "DeviceDMA = 5", and "DeviceID = 0xe015" to "DeviceID = 0xe018".
Also, I would recommend setting the CPU cycles to max in order to get Drone to run best, as it was designed to run on older Pentium processors.